A Comprehensive Research Review
Author: Alice Frolov
Field: Aging Biology, Molecular Biology, Biotechnology
Date: February 2026
Document Type: Comprehensive Scientific Review
II.E CELLULAR SENESCENCE
2.17 Discovery and Definition of Senescence
2.18 The Senescence-Associated Secretory Phenotype (SASP)
2.19 Accumulation of Senescent Cells with Aging
II.F STEM CELL EXHAUSTION
2.20 Stem Cells: Guardians of Tissue Renewal
2.21 Age-Related Changes in Stem Cells
2.22 Intrinsic vs. Extrinsic Contributions
2.23 Reversibility: Can Stem Cell Function Be Restored?
II.G LOSS OF PROTEOSTASIS
2.24 Proteostasis Networks: Maintaining Protein Quality